The seal itself was made from hard stone, glass, or ceramics such as Egyptian faience. Many varieties of material such as hematite, obsidian, steatite, amethyst and carnelian were used to make cylinder seals, but lapis lazuli was especially popular because of the beauty of the blue stone and as The alluvial country of Mesopotamia lacks good stone for carving; hence the large stones of early cylinders were imported probably from Iran.

While most Mesopotamian cylinder seals form an image through the use of depressions in the cylinder surface (see lead photo above), some cylinder seals print images using raised areas on the cylinder (see San Andrés image below). The former are used primarily on wet clays; the latter, sometimes referred to as roller stamps, are used to print images on cloth and other similar two dimensional surfaces.

Cylinder seals are a form of impression seal, a category which includes the stamp seal and finger ring seal.

Cylinder seal impressions were made on a variety of surfaces:

The images depicted on cylinder seals were mostly theme-driven, often sociological or religious. Instead of addressing the authority of the seal, a better study may be of the thematic nature of the seals, since they presented the ideas of the society in pictographic and text form. In a famous cylinder depicting Darius I of Persia: he is aiming his drawn bow at an upright enraged lion impaled by two arrows, while his chariot horse is trampling a deceased lion. The scene is framed between two slim palm trees, a block of cuneiform text, and above the scene, the Faravahar symbol of Ahura Mazda, the god representation of Zoroastrianism.

The reference below, Garbini, covers many of the following categories of cylinder seal.

A categorization of cylinder seals: